An efficient synthesis of optically active five- and six-membered cyclic compounds with selectable stereo-controls by a Ti(II)-mediated cyclization of chiral secondary 2,7- and 2,8-enyn-1-ol derivatives

✍ Scribed by Yongcheng Song; Yuuki Takayama; Sentaro Okamoto; Fumie Sato

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 376 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02695-3

✦ Synopsis

Ti(II)-mediated cyclization of readily accessible optically active secondary 2,7-and 2,8-enyn-1-ol derivatives enables the selective preparation of any one of the four possible stereoisomers of the cyclized product with high optical purity.