Kinetic resolution of (R,S)-1,2-isopropylidene glycerol (solketal) ester derivatives by lipases
✍ Scribed by Antônio C.O. Machado; Angelo A.T. da Silva; Cristiano P. Borges; Alessandro B.C. Simas; Denise M.G. Freire
- Book ID
- 113804790
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 348 KB
- Volume
- 69
- Category
- Article
- ISSN
- 1381-1177
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The lipase TL ® -mediated kinetic resolution of (±)-benzoin (1) proceeded to give the corresponding optically pure benzoin (R)-1. On the other hand, (S)-benzoin-O-acetate (5) could be hydrolyzed without epimerization to give (S)-benzoin (S)-1, under alkaline conditions. Further, (R)-1 was converted
Enantiomerically pure (R)-l-phenylethylamine and ethyl rac-2methyloctanoate in the presence of lipase from Candidada antarctica (Novozym 435) reacted to give (R)-2-methyloctanoic (R)-l-phenylethylamide as the predominant diastereomer of 30 -40% de at = 100% conversion. Ethyl rac-2-methyldecanoate an