𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Dynamic kinetic resolution of (R, S)-naproxen 2,2,2-trifluoroethyl ester via lipase-catalyzed hydrolysis in micro-aqueous isooctane

✍ Scribed by Han-Yuan Lin; Shau-Wei Tsai


Book ID
114396026
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
136 KB
Volume
24-25
Category
Article
ISSN
1381-1177

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Lipase-catalyzed dynamic resolution of n
✍ Chun-Sheng Chang; Shau-Wei Tsai; Jimmy Kuo πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 124 KB πŸ‘ 1 views

A lipase-catalyzed enantioselective hydrolysis process under continuous in situ racemization of substrate by using trioctylamine as an organic base was developed for the production of (S)-naproxen from racemic naproxen thioesters in isooctane. Naproxen 2,2,2trifluoroethyl thioester and 45Β°C were sel

Lipase-catalyzed dynamic hydrolytic reso
✍ Wen-Yen Wen; I-Sin Ng; Shau-Wei Tsai πŸ“‚ Article πŸ“… 2006 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 177 KB

## Abstract The hydrolytic resolution of (__R__,__S__)‐2,2,2‐trifluoroethyl α‐chlorophenylacetate in water‐saturated isooctane containing Lipase MY(I) at 35 Β°C is selected as the best reaction condition for producing (__R__)‐α‐chlorophenyl acetic acid. The kinetic constants, and hence an enantiomer