Kinetic resolution of hydroxy vinylsilanes by lipase-catalyzed enantioselective acetylation
✍ Scribed by Waldemar Adam; Cordula Mock-Knoblauch; Chantu R. Saha-Möller
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 256 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
The lipase-catalyzed acetylation of a broad spectrum of configurations of the 2-hydroxy acids 1 were assigned by comparison of the gas-chromatographic data with that of racemic 2-hydroxy acids 1 to their 2-acetoxy acids 2 was shown to proceed with high enantioselectivity. Thus, the literature-known
An enzymatic method for the direct resolution of propranolol is described. Candida cylindracea lipase enantioselectively catalyzed N-acetylation of S-propranolol with isopropenyl acetate in isopropyl ether. The ee values of the two enantiomers of N-acetylpropranolol were determined by an HPLC equip