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Kinetic resolution of a racemic sulfide by enantioselective sulfoxide formation

โœ Scribed by Phillips, Michael L.; Berry, Donnis M.; Panetta, Jill A.


Book ID
119976678
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
449 KB
Volume
57
Category
Article
ISSN
0022-3263

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โœ Michael L Phillips; Jill A Panetta ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 373 KB

The kinetic resolution of tazofelone (1) has been reported. The resolution of this sulfide was accomplished via enantioselective sulfoxide formation with tert-Bu hydroperoxide in the presence of a chiral tartrate/titanium complex. The resolution was performed on analogues of compound 1 in order to e