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Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase

✍ Scribed by Ramón Hurtado-Guerrrero; Javier Peña-Dı́az; Andrea Montalvetti; Luis M Ruiz-Pérez; Dolores González-Pacanowska

Book ID
117103751
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
127 KB
Volume
510
Category
Article
ISSN
0014-5793

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Hemin-mediated oxidative inactivation of
Hemin-mediated oxidative inactivation of 3-hydroxy-3-methylglutaryl CoA reductase
✍ S. Usha Devi; T. Ramasarma 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 537 KB

Addition of hemoglobin, methemoglobin, hemin or hematin in the assay mixture of rat liver 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibited the activity of the enzyme. The inhibition by hemin was rapid, without any apparent dependence on time of preincubation. At 20 microM hemin, a maximum