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Kinetic determination of propranolol in tablets by oxidation with ceric sulphate

✍ Scribed by Salah M. Sultan; Saad A. Altamrah; Abdullah M. Aziz Alrahman; Ibrahim Z. Alzamil; Mohammed O. Karrar

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
433 KB
Volume
7
Category
Article
ISSN
0731-7085

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✦ Synopsis

A simple and accurate kinetic method for the determination of propranolol has been developed. Cerium(IV) sulphate (0.5 M) is used to oxidize propranolol in 2 M sulphuric acid at room temperature to the ketone form that absorbs light at a lambda max of 525 nm. The fixed-concentration method is used by recording the exact time, t(s), taken for the reaction to reach a fixed absorbance of 0.100. The unknown concentration, c(M), of propranolol is calculated from the equation: l/t = 0 0.000217 + 0.03 c. The method has been applied to the determination of propranolol in proprietary tablets and the results were compared with those obtained by the B.P. and other standard methods.

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