Kinetic cyanations of ketone enolates

✍ Scribed by Daniel Kahne; David B. Collum

• Book ID: 104243523
• Publisher: Elsevier Science
• Year: 1981
• Tongue: French
• Weight: 183 KB
• Volume: 22
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)92406-2

✦ Synopsis

Kinetic cyanations of ketone enolates using p-toluenesulfonyl cyanide provide efficient routes to B-ketonitriles. During the course of a natural product synthesis study going on in our laboratory we required a means of effecting the ketone cyanation illustrated in equation 1. Examination of existing methodologies used to prepare 8ketonitriles failed to uncover a completely acceptable solution. l-5 The