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Kinetic aspects of interactions between DNA and platinum complexes

✍ Scribed by Jiřı́ Kozelka; Franck Legendre; Franziska Reeder; Jean-Claude Chottard

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
215 KB
Volume
190-192
Category
Article
ISSN
0010-8545

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DNA-platinum interactions. Characterizat
DNA-platinum interactions. Characterization of solid DNAK2[PtCl4 complexes
✍ J.-P. Macquet; T. Theophanides 📂 Article 📅 1976 🏛 Elsevier Science 🌐 English ⚖ 564 KB

## A specific reaction of cis-dichlorodiammineplatinum-(II), cis-Pt(NH3& with the GC planes of DNA is reported. This interaction is localized on the N,(G) and the O,(G) sites forming a chelate without proton liberation. On the other hand, the reaction of Kz [PtCl,] with DNA (41% or 72% GC) is also s