Kilogram Synthesis of (S)-3-Aminopyran from l-Glutamic Acid
โ Scribed by Savage, Scott; Babu, Srinivasan; Zak, Mark; Mao, Zhongping; Cao, Jianhua; Ge, Yonghui; Ma, Dongxu; Jiang, Guoqiang
- Book ID
- 120408388
- Publisher
- Thieme Medical Publishers
- Year
- 2013
- Tongue
- English
- Weight
- 177 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0936-5214
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
L-Glutamic acid has been converted into a separable mixture of D-amicetonoand L-rhodinono-y-lactones by a sequence involving transformation into (S)-y-carboxy-y-butyrolactone (2), conversion of 2 into the corresponding methyl ketone by the diazoketone route, and selective reduction with zinc borohyd
A stereo-and enantio-specific synthesis of the natural1 occurring cis-%hydroxy-(L)-pipecolic acid (3) is described, starting from Z-(L -glutamic the key step involves c chsation of a Y, to trans-%hydroxy-(L -pipecolic acl 3 3 rotected chlorohydrin, and also gives access acid, .