Key papers from other journals - November 1998

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 35 KB
• Volume: 1
• Category: Article
• ISSN: 1464-3383
• DOI: 10.1016/s1464-3383(04)80008-3

✦ Synopsis

A recent paper from the Schultz group at Berkeley reports on the culmination of a longstanding interest in kinase inhibitor libraries (N.S. Gray et al., Science, (1998), 281, 533-538). Cyclin-dependent kinases (CDKs) play a pivotal role in the timing of cell division and inappropriate function of these enzymes is characteristic of a number of cancers. Consequently, inhibition of CDKs is a possible target for therapeutic intervention. Following the known activity of the purine olomucine (1), several libraries of compounds were prepared with the intention of selectively binding to the kinase ATP-binding site.