๐”– Bobbio Scriptorium
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Key papers from other journals

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
39 KB
Volume
1
Category
Article
ISSN
1464-3383

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โœฆ Synopsis

Matrix metalloproteinase inhibitors

Many inhibitors of the matrix metalloproteinases have been previously reported, several types being produce in combinatorial libraries. A recent paper describes the design of matrix metalloproteinase inhibitors based on diketopiperazines (DKPs) (A.K. Szardenings et al, J. Med. Chem., (1998), 41, 2194-2200). The synthesis of DKPs on solid-phase has been reported many times, but in this library the compounds contain a thiol group designed to chelate the catalytic metal ion.

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๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 35 KB

A recent paper from the Schultz group at Berkeley reports on the culmination of a longstanding interest in kinase inhibitor libraries (N.S. Gray et al., Science, (1998), 281, 533-538). Cyclin-dependent kinases (CDKs) play a pivotal role in the timing of cell division and inappropriate function of th