Ketones in the catalytic three-component “one-pot” Kabachnik-Fields synthesis of α-amino phosphonates
✍ Scribed by E. D. Matveeva; T. A. Podrugina; M. V. Prisyajnoy; N. S. Zefirov
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 388 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1573-9171
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📜 SIMILAR VOLUMES
A simple, efficient, and environmentally benign method for a three-component reaction of an amine, an aldehyde or a ketone, and diethyl phosphite catalyzed by Amberlite-IR 120 resin has been developed to afford a-amino phosphonates in high yields and short reaction times under solvent-free reaction
## Abstract CeCl~3~·7H~2~O has been utilized as an efficient Lewis acid catalyst for the three‐component coupling of aldehydes, aromatic amines, and diethylphosphite to produce α‐aminophosphonates under solvent‐free conditions. The advantages of this protocol are high yield, mild reaction condition