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Ketamine increases the striatal N-[11C]methylspiperone binding in vivo: positron emission tomography study using conscious rhesus monkey

โœ Scribed by Hirotaka Onoe; Osamu Inoue; Kazutoshi Suzuki; Hideo Tsukada; Takashi Itoh; Nobuko Mataga; Yasuyoshi Watanabe


Book ID
113127136
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
794 KB
Volume
663
Category
Article
ISSN
0006-8993

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By means of positron emission tomography the uptake and kinetics of N-(methyl-11C)clozapine in different brain regions have been studied in Rhesus monkeys. 11C-clozapine rapidly entered the brain and maximum radioactive uptake was seen 5-12 min after administration. Highest uptake was measured in th