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Brain kinetics of (R)- and (S)-[N-methyl-11C]ketamine in the rhesus monkey studied by positron emission tomography (PET)

✍ Scribed by Hartvig, Per; Valtysson, Johann; Antoni, Gunnar; Westerberg, Göran; Långström, Bengt; Moberg, Enrica Ratti; Øye, Ivar


Book ID
123233508
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
828 KB
Volume
21
Category
Article
ISSN
0969-8051

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By means of positron emission tomography the uptake and kinetics of N-(methyl-11C)clozapine in different brain regions have been studied in Rhesus monkeys. 11C-clozapine rapidly entered the brain and maximum radioactive uptake was seen 5-12 min after administration. Highest uptake was measured in th