Karyotypic evolution of chronic lymphocytic leukemia B cells
β Scribed by Christine L.Y. Lee; Louis A. Fernandez; Spencer H.S. Lee; Tarunendu Ghose
- Book ID
- 119103152
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 433 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0165-4608
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Sequential cytogenetic studies were performed on a minimum of two and a maximum of nine occasions (mean 3.6) on the peripheral blood leucocytes of 112 patients with B-CLL. On initial cytogenetic analysis, 58 had a normal karyotype and 64 had a clonal abnormality. Karyotypic evolution occurred in 18
In the present report we studied the phenotype of peripheral blood mononuclear cells (PBMC) from 25 patients with B-cell chronic lymphocytic leukemia (CLL). Cells from all the cases expressed monoclonal surface immunoglobulins (SmIg), formed rosettes with mouse erythrocytes (MRFC) and were positive