✦ LIBER ✦

Karyotypic evolution in B-cell chronic lymphocytic leukaemia

✍ Scribed by David Oscier; Margaret Fitchett; Tony Herbert; Richard Lambert

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 357 KB
Volume: 3
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870030104

No coin nor oath required. For personal study only.

✦ Synopsis

Sequential cytogenetic studies were performed on a minimum of two and a maximum of nine occasions (mean 3.6) on the peripheral blood leucocytes of 112 patients with B-CLL. On initial cytogenetic analysis, 58 had a normal karyotype and 64 had a clonal abnormality. Karyotypic evolution occurred in 18 patients (16%). There was no significant difference in the incidence of disease progression between patients with a stable karyotype and those who underwent karyotypic evolution. In only one patient was there a clear association between disease progression, a change in cell morphology and karyotypic evolution.

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