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Certain patterns of karyotype evolution in chronic myelogeneous leukaemia

✍ Scribed by E. L. Prigogina; E. W. Fleischman

Publisher
Springer
Year
1975
Tongue
English
Weight
842 KB
Volume
30
Category
Article
ISSN
0340-6717

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✦ Synopsis

The study of chromosome banding pattern of leukaemic cells in 15 patients with CML revealed t(9;22) in all cases. Similar additional chromosome abnormalities were observed in the terminal stage of the disease in 5 of 9 patients with aneuploid cell lines. The most frequent abnormalities were i(17q) and trisomy 8. The regularities of karyotype evolution in the terminal stage of CML are discussed.

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