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Jumping Translocation of Homogeneously Staining Region and Tetraploidy with Double Minutes in Acute Myelomonocytic Leukemia

✍ Scribed by Tetsuya Yoshida; Nobuhiro Kimura; Tomi Akiyoshi; Koichi Ohshima; Mitsuyuki Nagano; Eiji Morioka; Syusuke Hisano; Kazuma Ohyashiki; Nanao Kamada; Kazuo Tamura


Book ID
114136824
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
1006 KB
Volume
109
Category
Article
ISSN
0165-4608

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Amplification of the MLL gene on double
✍ Berthold Streubel; Peter Valent; Ulrich JΓ€ger; Martin EdelhΓ€user; Hannes Wandt; πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 184 KB πŸ‘ 2 views

Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi