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Determination of chromosomal area of double minute chromosomes and a homogeneously staining region in HL-60 human leukemia cells by the use of a color image analyzer

✍ Scribed by Shinichi Misawa; Tatsuo Abe; Tetsuro Takamatsu; Setsuya Fujita; Joseph R. Testa

Publisher
Nature Publishing Group
Year
1986
Tongue
English
Weight
916 KB
Volume
31
Category
Article
ISSN
1435-232X

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Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi