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Acute myeloid leukemia with MYC amplification in the homogeneous staining regions and double minutes

✍ Scribed by Seungok Lee; Myungshin Kim; Jihyang Lim; Yonggoo Kim; Kyungja Han; Hee-Je Kim; Seok-Goo Cho; Woo-Sung Min

Book ID
113513553
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
185 KB
Volume
192
Category
Article
ISSN
0165-4608

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Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi