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Isozyme specificity of novel glutathione-S-transferase inhibitors

✍ Scribed by Jeffrey E. Flatgaard, Karin E. Bauer…

Book ID
120777355
Publisher
Springer
Year
1993
Tongue
English
Weight
847 KB
Volume
33
Category
Article
ISSN
0344-5704

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Glutathione S-transferases (GST, E.C.2.5.1.18) comprise a family of detoxification enzymes. Elevated levels of specific GST isozymes in tumor cells are thought responsible for resistance to chemotherapeutics, which renders selective GST inhibitors potentially useful pharmaceutical agents. We discuss