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Isoenzyme-specific glutathione-S-transferase inhibitors: design and synthesis

✍ Scribed by Lyttle, Matthew H.; Hocker, Michael D.; Hui, Hon C.; Caldwell, Colby G.; Aaron, Decius T.; Engqvist-Goldstein, Asa; Flatgaard, Jeffrey E.; Bauer, Karin E.

Book ID
126192520
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
913 KB
Volume
37
Category
Article
ISSN
0022-2623

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Glutathione S-transferases (GST, E.C.2.5.1.18) comprise a family of detoxification enzymes. Elevated levels of specific GST isozymes in tumor cells are thought responsible for resistance to chemotherapeutics, which renders selective GST inhibitors potentially useful pharmaceutical agents. We discuss