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Isosorbide 5-mononitrate kinetics

✍ Scribed by Major, R M; Taylor, T; Chasseaud, L F; Darragh, A; Lambe, R F


Book ID
109843592
Publisher
Nature Publishing Group
Year
1984
Tongue
English
Weight
457 KB
Volume
35
Category
Article
ISSN
0009-9236

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## Abstract When isosorbide 5‐mononitrate was intravenously infused at a rate of 4 mg h ^βˆ’1^ for 2.5 h to five human subjects, its concentrations in plasma increased slowly to 185 ng ml^βˆ’1^ Β± 5 per cent C.V. at 2.5 h and a steady‐state plasma level was not reached during the infusion. When the infu