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Isosorbide 5-mononitrate and isosorbide 2-mononitrate kinetics after intravenous and oral dosing

✍ Scribed by Straehl, P; Galeazzi, R L; Soliva, M

Book ID
109843459
Publisher
Nature Publishing Group
Year
1984
Tongue
English
Weight
373 KB
Volume
36
Category
Article
ISSN
0009-9236

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## Abstract When isosorbide 5‐mononitrate was intravenously infused at a rate of 4 mg h ^βˆ’1^ for 2.5 h to five human subjects, its concentrations in plasma increased slowly to 185 ng ml^βˆ’1^ Β± 5 per cent C.V. at 2.5 h and a steady‐state plasma level was not reached during the infusion. When the infu