## Abstract When isosorbide 5βmononitrate was intravenously infused at a rate of 4 mg h ^β1^ for 2.5 h to five human subjects, its concentrations in plasma increased slowly to 185 ng ml^β1^ Β± 5 per cent C.V. at 2.5 h and a steadyβstate plasma level was not reached during the infusion. When the infu
Pharmacokinetics of intravenous and oral isosorbide-5-mononitrate
β Scribed by U. Abshagen; G. Betzien; R. Endele; B. Kaufmann
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 589 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0031-6970
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Pharmacokinetics of 20 mg isosorbide-5-mononitrate (IS-5-MN) after single and multiple administration of two different tablet formulations were investigated in twelve healthy human subjects using an open, randomized, two-way crossover experimental design. Pentacard@ 20 mg tablets were compared with
The possibility of a pharmacokinetic interaction between isosorbide-5-mononitrate (5-ISMN) and epinine, the active metabolite of ibopamine, has been investigated in 8 healthy male subjects given single doses of 200 mg ibopamine and 20 mg 5-ISMN, separately and together. The plasma 5-ISMN concentrati