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Isomerization of propargylic alcohols catalyzed by an iridium complex

✍ Scribed by Dawei Ma; Xiyan Lu

Book ID
104244808
Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
273 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

a,B-Enones were synthesized by the isomerization of propargylic alcohols catalyzed by an iridium pentahydride complex.

a,@-Enones are well known as important intermediateslin organic synthesis, especially in the synthesis of natural products.

A series of new approaches has been reported for the preparation of this class of compounds including the Horner-Emmons-Wadsworth reaction, elimination and condensation reactions, 1J Many of them, however, follow lengthy procedures and need starting materials not easy to prepare. The synthesis of rr,fi-enones using propargylic alcohols as starting materials should be also beneticial due to-

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## Abstract **Unter sehr milden Reaktionsbedingungen** vermitteln Iridiumhydridkatalysatoren die Isomerisierung primärer Allylalkohole. Die besten Katalysatoren, darunter (__R__)‐**1**, liefern die gewünschten chiralen Aldehyde mit ausgezeichneten Enantioselektivitäten und in guten Ausbeuten. Auf d

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## Abstract **Nothing to sm(Ir)k at**: Under appropriate reaction conditions, iridium hydride catalysts promote the isomerization of primary allylic alcohols. The best catalysts, like (__R__)‐**1** (P green, O red, N blue, Ir yellow), deliver the desired chiral aldehydes with excellent enantioselec