## Abstract Beide Enantiomeren des Pyridonalkaloids Melochinin (**1**) werden auf folgende Weise synthetisiert: Bei der Deprotonierung von 3‐Hydroxy‐2,6‐dimethyl‐4‐pyron (**3**) mit Lithium‐bis(trimethylsilyl)amid bei ‐ 70°C entsteht ausschließlich das Dienolat‐Dianion **3a**. Es reagiert bei diese
Isomazol, Synthese der Enantiomeren
✍ Scribed by R. Jonas; H. Wurziger
- Book ID
- 101642039
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 162 KB
- Volume
- 319
- Category
- Article
- ISSN
- 0365-6233
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## Abstract Two new syntheses of spiro[4.4]nonane‐1, 6‐dione (I) are described: one by rearrangement of 1,6‐epoxy‐bicyclo[4.3.0]‐nonane‐2‐one (IV) with boron trifluoride, the other by an acid catalyzed, intramolecular __Claisen__ condensation of 4‐(2‐oxocyclopentyl)‐butyric acid. Spiro[4.4]‐nonane‐
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