We investigated continuous production of Inoue-Melnick virus (IMV) in the MG-1 cell line, established from human meningioma. The infectious virus, identified as a type 1 virus, was mostly recovered extracellularly. Assay of MG-1 cells as infective centers indicated that most of the cells were capabl
Isolation of inoue-melnick virus from human meningioma-derived cell cultures and detection of antibody in patients with meningioma
โ Scribed by Dr. Y. K. Inoue; Y. Nishibe; J. Takeuchi; Y. Uchida; H. Handa; A. C. Hollinshead
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 262 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0146-6615
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โฆ Synopsis
Inoue-Melnick virus (IMV) was isolated from six of seven human meningiomaderived cell cultures, while the virus was not isolated from six other brain tumor cell cultures. Sera of 145 consecutive neurosurgical inpatients were tested for IMV-neutralizing antibody. Of 26 patients with meningioma, 22 were positive for IMV antibody (84.6%). Of the remaining 119 patients, 16 were positive.
๐ SIMILAR VOLUMES
## Abstract The antibody prevalence rate of 3 types of IMV in 24 sera of Japanese patients with colorectal adenocarcinoma (mean age 60.8 years) was 83.3% (20/24). Of 20 positive sera, 19 contained type 1 antibody and one contained type 2. In contrast, the seropositivity of IMV in 21 sera of matched