Detection of Inoue-Melnick virus (IMV)-antibody in Japanese patients with colorectal carcinoma and isolation of IMV from Japanese colorectal carcinoma cell lines

✍ Scribed by Y. Nishibe; Dr. Y. K. Inoue; Y. Nakamura

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 307 KB
• Volume: 32
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890320403

✦ Synopsis

Abstract

The antibody prevalence rate of 3 types of IMV in 24 sera of Japanese patients with colorectal adenocarcinoma (mean age 60.8 years) was 83.3% (20/24). Of 20 positive sera, 19 contained type 1 antibody and one contained type 2. In contrast, the seropositivity of IMV in 21 sera of matched control patients (mean age 60.9 years) with non‐colorectal carcinoma such as mammary and lung carcinoma was 23.8% (5/21). The 5 positive sera contained type 1 antibody. The seropositivity to IMV in 79 sera of healthy Japanese over 50 years of age (mean age 62.3 years) was 24.0% (19/79). Again all of the 19 positive‐sera contained type 1 antibody. The seropositivity of IMV in the patient with colorectal adenocarcinoma was significantly higher than in the controls, non‐colorectal carcinoma patients and healthy persons over 50 years of age (P<0.001). Type 1 IMV was isolated from each of 2 recently established Japanese colorectal adenocarcinoma cell lines.