Isolation of chromosome-21-specific DNA probes and their use in the analysis of nondisjunction in Down syndrome
โ Scribed by J. Galt; E. Boyd; J. M. Connor; M. A. Ferguson-Smith
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 682 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A recombinant clone was isolated containing a sequence which occurs only on human chromosome 21 and defines a two-allele restriction fragment length polymorphism showing Mendelian inheritance. Forty seven percent of the London population are heterozygous for the polymorphism. The chromosomal locatio
Linkage studies in families with presenile onset of Alzheimer's disease (AD) indicated the presence of a predisposing gene on the proximal long arm of chromosome 21. We mapped four new loci in the candidate AD region using somatic cell hybrids. For three of the four loci, several restriction fragmen