Linkage studies in families with presenile onset of Alzheimer's disease (AD) indicated the presence of a predisposing gene on the proximal long arm of chromosome 21. We mapped four new loci in the candidate AD region using somatic cell hybrids. For three of the four loci, several restriction fragmen
โฆ LIBER โฆ
Selection of human chromosome 21-specific DNA probes for genetic analysis in Alzheimer's dementia and Down syndrome
โ Scribed by Guy Camp; Piet Stinissen; Wim Hul; Hubert Backhovens; Anita Wehnert; Antoon Vandenberge; Christine Broeckhoven
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 463 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Identification of chromosome 21 DNA poly
โ
G. Camp; H. Backhovens; M. Cruts; A. Wehnert; W. Hul; P. Stinissen; C. Broeckhov
๐
Article
๐
1991
๐
Springer
๐
English
โ 542 KB
Isolation of chromosome-21-specific DNA
โ
J. Galt; E. Boyd; J. M. Connor; M. A. Ferguson-Smith
๐
Article
๐
1989
๐
Springer
๐
English
โ 682 KB
Use of a chromosome 21 cloned DNA probe
โ
K. E. Davies; K. Harper; D. Bonthron; R. Krumlauf; A. Polkey; M. E. Pembrey; R.
๐
Article
๐
1984
๐
Springer
๐
English
โ 570 KB
A recombinant clone was isolated containing a sequence which occurs only on human chromosome 21 and defines a two-allele restriction fragment length polymorphism showing Mendelian inheritance. Forty seven percent of the London population are heterozygous for the polymorphism. The chromosomal locatio