Isolation of anti-idiotypic antibodies to T cells using an anti-framework determinant antibody
β Scribed by Holden T. Maecker; Kiyoshi Kitamura; Michael B. Brenner; Ronald Levy
- Book ID
- 118900530
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 698 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0022-1759
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We examined the possibility of using affinity columns coupled with anti-idiotype (Id) antibodies to selectively remove nephritogenic anti-DNA antibodies in order to determine their possible application to therapeutic plasmapheresis. Monoclonal anti-Id antibodies termed D1E2 or 1F5 were directed to i
## Abstract A small dose of the IgG~1~ fraction of antiβidiotypic antibody (ΔId 1) raised in guinea pigs against a strain A/J antibody specific for streptococcal Group A carbohydrate sensitizes A/J mice against Group A streptococci. This is opposed to the previously established suppressive function