Isolation in newborn mice of tumour cell variants from a polyoma-transformed non-malignant cell line
β Scribed by E. Hunter; G. Negroni
- Book ID
- 113145268
- Publisher
- Elsevier Science
- Year
- 1972
- Weight
- 281 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0014-2964
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Two cell lines, RVP3 and RVA4, derived originally from mouse tumors induced by the Prague and Schmidt-Ruppin strain of RSV, respectively, were studied. tall attempts failed to induce infectious virus production in RVP3 cells by fusion with chicken fibroblasts even if the cells were infected with avi
## Abstract Cells transformed after treatment with the chemical carcinogen dimethylnitrosamine (DMNA) inoculated into animals, can produce tumors containing variants with a reversion of in vitro properties of transformed cells. In contrast to variants from tumors produced by polyomaβtransformed cel