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The formation of variants with a reversion of properties of transformed cells. VIII. in vitro limited life span of variants isolated from tumors

✍ Scribed by Zelig Rabinowitz; Leo Sachs

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
434 KB
Volume
10
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Cells transformed after treatment with the chemical carcinogen dimethylnitrosamine (DMNA) inoculated into animals, can produce tumors containing variants with a reversion of in vitro properties of transformed cells. In contrast to variants from tumors produced by polyoma‐transformed cells, 83% of the variants in tumors from DMNA‐transformed cells had again acquired, like normal cells, a limited life‐span. in vitro. Seventeen % of the variants escaped the termination of their life‐span by re‐reverting to the transformed state.

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