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The formation of variants with a reversion of properties of transformed cells. VII. Chromosome numbers and re-reversion in subtetraploid variants

✍ Scribed by Shinya Hitotsumachi; Rina Schaki; Baruch Padeh; Zelig Rabinowitz; Leo Sachs

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
294 KB
Volume
10
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Variants from polyoma virus transformed cells in which reversion was not associated with a loss of the virus genome have been studied at 3 and 33 weeks after clone isolation. The variants re‐reverted during this in vitro cultivation for properties which were initially suppressed. This re‐reversion was associated with an increase in the total chromosome number from a lower to a higher subtetraploid chromosome number.

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## Abstract Cells transformed after treatment with the chemical carcinogen dimethylnitrosamine (DMNA) inoculated into animals, can produce tumors containing variants with a reversion of in vitro properties of transformed cells. In contrast to variants from tumors produced by polyoma‐transformed cel