Isolation and Synthesis of 2-Chloro-10-α-hydroxynaltrexone, a New Naltrexone Degradant.
✍ Scribed by Walter Meredith; Gregory A. Nemeth; Robert Boucher; Robert Carney; Michael Haas; Ken Sigvardson; Christopher A. Teleha
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 63 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract p‐Chloro[^14^C]mandelic acid **2** was prepared from [^14^C]potassium cyanide and p‐chlorobenzaldehyde **1**. The condensation of p‐chloro[^14^c] mandelic acid with 1,2‐diamino benzene **3** gave the title benzimidazole **4** labelled at the carbon atome 2 of the heterocyclic ring.
Two new istamycin components have been isolated from culture filtrates of Streptomyces tenjimariensis. Their structures were suggested to be 2"-N-formimidoylistamycins A and B by spectral analysis, and confirmed by synthesis starting from istamycins A, and BO, respectively. \*Dedicated to Professor
nitrogen source. The bright-blue reagent 1, readily accessible by chlorination of cyclohexanone oxime [4], can safely be stored for a least 1 year at -30" but is preferably distilled in vacuo before use. In contrast to infamous N-nitroso derivatives, C-nitroso compound 1 proved not to be mutagenic i