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Isolation and preliminary characterization of rat liver cells resistant to 7-ketocholesterol

✍ Scribed by David A. Rintoul; Robert D. Simoni

Book ID
115737676
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
955 KB
Volume
531
Category
Article
ISSN
0005-2760

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## Abstract Stable mutants resistant to an anticancer antibiotic, bleomycin‐A2, were selected in Chinese hamster ovary (CHO) cell either spontaneously or after ethylmethane sulfonate mutagenesis. Fluctuation analysis showed that bleomycin resistance occurs in CHO at a rate of 6.50–6.58 Γ— 10^βˆ’7^ mut