## Abstract 3α‐Hydroxy‐5α‐pregnane‐11,20‐dione‐2,2,3,4,4‐^2^H~5~ of 78% isotopic purity was prepared from 3α‐hydroxy‐5α‐pregnane‐11,20‐dione. The major impurity (10%) was 3α‐hydroxy‐5α‐pregnane‐11,20‐dione‐2,2,4,4‐^2^H~4~. 3α,21‐Dihydroxy‐5α‐pregnane‐11,20‐dione‐2,2,3,4,4‐^2^H~5~ 21‐acetate of 76%
Isolation and identification of 3α,21-dihydroxy-5α-pregnane-11,20-dione from urine
✍ Scribed by Willard R. Starnes; Theresa F. Partlow
- Publisher
- Elsevier Science
- Year
- 1965
- Tongue
- English
- Weight
- 315 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0003-2697
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Crystal and Molecular Structure of 17a,21-Dihydroxy-l,4-Pregnadiene-3,2O-Dione The title compound 17~,21-dihydroxy-l,4-pregnadiene-3,20-dione crystalIizes in the orthorhombic space group P 212121 with four molecules in the unit cell and the lattice parameters a = 7.727, b = 10.095, c = 22.876 A. The
## Abstract In order to fully understand the metabolic transformations of adrenocortical steroids, labelled 3α, 11β 17α,211‐tetrahydroxy‐5α‐pregnan‐20‐one, Reichstein's Compound C was required. Starting from hydrocortisone, the synthesis of [1−^3^H]‐Reichstein's Compound C has been accomplished.
3p-hydroxy-ateroidm, i a deacribed: 3p, 1 1 p-di hydroxy-5-androaten-17-one, 5-pregnene-3ps 1lP,17ab2Oa-tetrol and 5-preqnene-3p,1lps 17a , top-tetrol.
The completely assigned 1H and 13C NMR spectra of the title diastereoisomers in solutions of and CDCl 3 are reported. NOE experiments show that these molecules adopt speciÐc conformations with no rota-DMSO-d 6 tion about the C-2ÈN bond in either solvent. In ring A of the steroid is in a twist-boat c