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2H-labelled 3α-hydroxy-5α-pregnane-11,20-dione and 3α,21-dihydroxy-5α-pregnane-11,20-dione 21-acetate

✍ Scribed by J. Vine; K. Treloar

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
308 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

3α‐Hydroxy‐5α‐pregnane‐11,20‐dione‐2,2,3,4,4‐^2^H~5~ of 78% isotopic purity was prepared from 3α‐hydroxy‐5α‐pregnane‐11,20‐dione. The major impurity (10%) was 3α‐hydroxy‐5α‐pregnane‐11,20‐dione‐2,2,4,4‐^2^H~4~. 3α,21‐Dihydroxy‐5α‐pregnane‐11,20‐dione‐2,2,3,4,4‐^2^H~5~ 21‐acetate of 76% isotopic purity was prepared by reaction of the deuterated 3α‐hydroxy compound with lead tetraacetate. The major impurity (10%) was 3α,21‐dihydroxy‐5α‐pregnane‐11,20‐dione‐2,2,4,4‐^2^H~4~.

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