Communicated by Victor A. McKusick von Hippel-Lindau disease (VHL) is an inherited neoplastic disorder characterized by the development of tumors in the eyes, brain, spinal cord, inner ear, adrenal gland, pancreas, kidney, and epididymis. The VHL tumor suppressor gene was identified in 1993. Initial
Isolation and characterization of the full-length 3′ untranslated region of the human von Hippel-Lindau tumor suppressor gene
✍ Scribed by P. Renbaum; Fuh-Mei Duh; Farida Latif; Berton Zbar; Michael I. Lerman; Igor Kuzmin
- Book ID
- 106136500
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 62 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0340-6717
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Von Hippel-Lindau disease is a heritable tumour syndrome caused by the loss of the function of a tumour suppressor gene on the short arm of human chromosome 3. The interval RAF1-D3S18 (3p25-3p26) has been identified by genetic linkage studies to harbour the von Hippel-Lindau gene. We have constructe