Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene
✍ Scribed by Levy, Andrew P; Levy, Nina S; Iliopoulos, Othon; Jiang, Chian; Kaelin, William G; Goldberg, Mark A
- Book ID
- 109885048
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 382 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0085-2538
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## Abstract Hypoxia–inducible factor (HIF) remains the central focus of oxygen sensing during hypoxia. HIF is a heterodimeric transcription factor consisting of an oxygen‐regulated alpha‐ and a constitutively expressed beta subunit. The von Hippel‐Lindau tumor suppressor (pVHL) is a component of th
## Abstract ## BACKGROUND A high frequency of genetic alterations of the von Hippel‐Lindau (__VHL)__ gene and overexpression of the vascular endothelial growth factor (__VEGF)__ gene have been observed independently in human sporadic renal cell carcinoma (RCCs), but to the authors' knowledge the a