Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel–Lindau tumor suppressor gene
✍ Scribed by Blouw, B; Haase, V H; Song, H; Bergers, G; Johnson, R S
- Book ID
- 110072248
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 527 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## BACKGROUND A high frequency of genetic alterations of the von Hippel‐Lindau (__VHL)__ gene and overexpression of the vascular endothelial growth factor (__VEGF)__ gene have been observed independently in human sporadic renal cell carcinoma (RCCs), but to the authors' knowledge the a
## Abstract ## Background Neoangiogenesis is essential for tumor growth. The present study aimed to test the hypothesis that vector‐mediated expression of sflt1 at high levels would result in the blockade of vascular endothelial growth factor (VEGF) function and therefore the inhibition of tumor g