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Isoenzyme-specific activation of nitrosamines in genetically engineered V79 cells expressing cytochrome P-450 2B1 and 2E1 isoenzyme

✍ Scribed by Janzowski, C.; Landsiedel, R.; Schneider, H.; Schmalix, W.A.; Doehmer, J.; Eisenbrand, G.

Book ID: 122785625
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 116 KB
Volume: 74
Category: Article
ISSN: 0378-4274
DOI: 10.1016/0378-4274(94)90312-3

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## Abstract Genetic engineering of target cells for investigating the genotoxicity associated with specific xenobiotic‐metabolizing enzymes is useful for elucidating metabolic activation and inactivation processes. We constructed a V79‐derived cell line expressing both human cytochrome P450 (CYP) 2