Isochromosome for the long arm of the Y in an infertile male
โ Scribed by Mark C. Taylor; H. Allen Gardner; C. Ezrin
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 256 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0340-6717
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โฆ Synopsis
A 37-year-old man investigated for infertility had bilateral atrophic testes. Cytogenetic investigations revealed a chromosome complement of 45,XO/46,Xi(Yq)/46,XY. Mechanisms for the origin of the i(Yq) are considered, and the relation of his chromosome constitution to his infertility and hypogonadism are discussed.
๐ SIMILAR VOLUMES
We report the prenatal findings of mos 46,XY/46,XY,i(20q) after amniocentesis. The propositus presented with two epidermal scalp scars, retrobulbar orbital cysts, and dyssegmentation of the thoracic spine. The abnormal cell line was discovered in cells cultured from the proximal umbilical cord and-b
H-Y antigen expression was detected on cells from an individual having a presumptive 45,X/46,X,i(Yp) karyotype, but was absent on cells from another person having a 46,X,i(Yq) karyotype. This suggests that the short arm of the human Y chromosome is essential for H-Y antigen expression, at least in t