Is substantia nigra echogenicity related to the dopaminergic nigrostriatal impairment in Parkinson’s disease?
✍ Scribed by L. Niehaus; R. Steinke; M. Glaser; H.J. Heinze; B. Schott
- Book ID
- 118434447
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 37 KB
- Volume
- 118
- Category
- Article
- ISSN
- 1388-2457
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## Abstract ## Background: Substantia nigra hyperechogenicity assessed by transcranial sonography is a typical finding in up to 90% of patients with idiopathic Parkinson's disease, although its value as a surrogate marker for disease progression in Parkinson's disease is controversial. ^123^I‐FP‐C
## Abstract Transcranial sonography (TCS) reveals abnormal spatial extension of substantia nigra (SN) echogenicity in a high proportion of patients with Parkinson's disease (PD). It has been proposed that this abnormality represents a structural trait that is mechanistically distinct from degenerat