Substantia nigra echogenicity is correlated with nigrostriatal impairment in Machado-Joseph disease
✍ Scribed by Pedroso, José Luiz; Bor-Seng-Shu, Edson; Felício, André C.; Braga-Neto, Pedro; Hoexter, Marcelo Q.; Teixeira, Manoel Jacobsen; Bressan, Rodrigo A.; Barsottini, Orlando Graziani Povoas
- Book ID
- 120712769
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 496 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1353-8020
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## Abstract ## Background: Substantia nigra hyperechogenicity assessed by transcranial sonography is a typical finding in up to 90% of patients with idiopathic Parkinson's disease, although its value as a surrogate marker for disease progression in Parkinson's disease is controversial. ^123^I‐FP‐C
## Abstract Transcranial sonography (TCS) reveals abnormal spatial extension of substantia nigra (SN) echogenicity in a high proportion of patients with Parkinson's disease (PD). It has been proposed that this abnormality represents a structural trait that is mechanistically distinct from degenerat