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Is droplet evaporation crucial in the mechanism of electrospray mass spectrometry?

✍ Scribed by K. W. M. Siu; R. Guevremont; J. C. Y. Le Blanc; R. T. O'Brien; S. S. Berman

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 566 KB
Volume: 28
Category: Article
ISSN: 1076-5174
DOI: 10.1002/oms.1210280519

No coin nor oath required. For personal study only.

✦ Synopsis

Evaporation of solvent from charged droplets was found not to be a prerequisite to ion desorption in electrospray mass spectrometry. Evidence of evaporation was absent in an examination of the electrospray mass spectral pro- files of cytochrome c and myoglobin in 0.2% acetic and propionic acid solutions; the pHs of these two acid solutions are expected to change in opposite directions with evaporation. The results strongly suggest that ions, as observed in electrospray mass spectrometry, are desorbed from solutions that have undergone minimal evaporation, in other words, at the beginning rather than later parts of the electrospray process. It is speculated that ions are desorbed directly from the solution-air interface at the needle tip.

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