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Is CYP2C9 polymorphism associated with colorectal cancer risk?

✍ Scribed by Mehtap Vefai; Buket Alpertunga; Gül Özhan

Book ID
116925218
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
85 KB
Volume
211
Category
Article
ISSN
0378-4274

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CYP17 encodes the enzyme cytochrome P-450c17␣, which mediates both 17␣-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog