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CYP2C19*17 is associated with decreased breast cancer risk

✍ Scribed by Christina Justenhoven; Ute Hamann; Christiane B. Pierl; Christian Baisch; Volker Harth; Sylvia Rabstein; Anne Spickenheuer; Beate Pesch; Thomas Brüning; Stefan Winter; Yon-Dschun Ko; Hiltrud Brauch

Publisher
Springer US
Year
2008
Tongue
English
Weight
178 KB
Volume
115
Category
Article
ISSN
0167-6806

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CYP17 encodes the enzyme cytochrome P-450c17␣, which mediates both 17␣-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog